Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe

By Mancia Giuseppe

Considering that angiotensin II is among the such a lot effective vasoconstrictors and a massive stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a crucial step in regulating blood strain. This type of drug is well-tolerated via pateints and those medicinal drugs have the additional virtue over ACE inhibitors in that they're now not linked to cough. simply because such a lot medicines could be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive impression together with diuretics, they seem to be a welcome healing instrument within the therapy of high blood pressure. This moment version builds at the good fortune of the 1st and brings to the reader the entire newest advancements, medical trial facts, and the contributors's own views while treating sufferers with angiotensin II receptors antagonists.

  • offers chapters via recognized participants within the fields of either high blood pressure and middle failure, specifically in regards to pharmacological interventions
  • covers the recent function of AIIR in neuroprotection
  • builds upon the strengths of the 1st edition
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    Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005; 19:617–19. 28. Yang Z, Bove CM, French BA et al. Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction. Circulation 2002; 106:106–11. 29. Metcalfe BL, Huentelman MJ, Parilak LD et al. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension 2004; 43:1233–8. 30. Armando I, Jezova M, Juorio AV et al. Estrogen upregulates renal angiotensin II AT(2) receptors.

    De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000; 52:415–72. 2. Berk BC. Angiotensin type 2 receptor (AT2R): a challenging twin. Sci STKE 2003; 2003:PE16. 3. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. Edinburgh: Churchill Livingstone, 2003. 4. Landon EJ, Inagami T. Beyond the G protein: the saga of the type 2 angiotensin II receptor. Arterioscler Thromb Vasc Biol 2005; 25:15–16. 5. Senbonmatsu T, Saito T, Landon EJ et al.

    G. mRNA quantification in different organs or effects of simultanous AT2R blockade) were obtained in human clinical studies. As regards the apparent beneficial effects of an ARB–ACE inhibitor combination, it should be mentioned that there is hardly a study in which a high-dose ARB regimen is compared with a high-dose ARB–ACE inhibitor combination. We would like to conclude with the fascinating observation that lifelong treatment of strokeprone spontaneously hypertensive rats with an ARB doubles the life span compared with placebo,102 which putatively also involves AT2Rs, considering the discussion above.

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